Job Description

**Senior Research Associate, MOA of Cancer Therapeutics, Disease Mechanism Research** Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas! Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at . This position is based in South San Francisco, CA. Remote work from certain states may be permitted in accordance with Astellas' Responsible Flexibility Guidelines. Candidates interested in remote work are encouraged to apply. **Purpose and Scope:** The Disease Mechanism Research team at Astellas West Coast Innovation Center is looking for a passionate and driven individual to join our fast-paced team. This position will support oncology disease mechanism research with a dynamic drug discovery environment. The scientist will apply deep expertise in cell culture and immuno-oncology to advance experimental strategies and data generation. This role will contribute towards efforts of understanding drug and disease mechanisms of action and will require collaboration with internal and external project teams to drive progress towards research milestones. This position will be located on site in South San Francisco. **Essential Job Responsibilities:** + Perform cell-based assays including cytotoxicity assay and flow cytometry to support the cancer biology research + Establishing cell lines from primary tumor tissue + Conduct molecular and biochemistry assays including Western Blot, ELISA, DNA/RNA extraction, PCR and qPCR + Independently design and execute experiments to generate high-quality and reproducible data to evaluate mechanisms of resistance and action of therapeutic molecules + Analyze experimental results using tools such as GraphPad Prism and FlowJo + Maintain accurate detailed, and well-organized electronic lab notebooks and experimental records + Collaborate and communicate effectively with team members and cross-functional groups to support project goals **Qualifications** **Required:** + B.S + 5 years' experience or M.S. + 3 years' experience + Proficiency in cell culture techniques, Flow cytometry, and nucleic acid/protein analysis assays + Demonstrated ability to independently plan and execute experiments with minimal supervision + Experience with primary tissue processing and establishment of primary cell culture lines + Strong data analysis skills with proficiency in tools such as GraphPad Prism and FlowJo + Excellent oral presentation skills **Preferred:** + Experience with Incucyte live cell imaging assay platform and SONY Cell Sorting platforms + Experience with Luminex platform + Familiar with next generation sequencing workflow is a plus **Working Environment:** + This position is based in South San Francisco, CA, USA and requires on-site work. **Salary Range:** $79,800-125,400 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations) **Benefits:** + Medical, Dental and Vision Insurance + Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down + 401(k) match and annual company contribution + Company paid life insurance + Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions + Long Term Incentive Plan for eligible positions + Company fleet vehicle for eligible positions + Referral bonus program \#LI-TR1 Category Cancer Biology Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans

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Summer holiday, Remote work,

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